Abstract 
Background: Skin and soft tissue infections (SSTIs) including cellulitis and abscess are common conditions managed in the emergency department, but differentiating these on history and physical examination alone can be challenging. Point-of-care ultrasound (POCUS) has been proposed as a tool to distinguish abscess from cellulitis.
Clinical question: What is the utility of POCUS for diagnosing soft tissue abscess vs. cellulitis?
Evidence review: Studies retrieved included four systematic reviews and meta-analyses evaluating the use of POCUS for diagnosing abscess. These studies provide estimates of the potential utility of POCUS in differentiating abscess and cellulitis.
Conclusion: Based upon the available literature, POCUS can reliably differentiate abscess and cellulitis and assist with management of SSTIs.
Keywords: POCUS; abscess; cellulitis; infectious disease; point-of-care ultrasonography; point-of-care ultrasound; soft tissue infection; ultrasonography; ultrasound.
