Podcast : O2 Targets

Nov 21, 2022

Contributor: Aaron Lessen,MD

Educational Pearls:

  • Recent study looked at mechanically ventilated patients in ED and ICU to determine if O2 saturation level impacted patient outcomes
    • 2541 patients randomized to one of three target O2 saturation levels
      • Low: 90% (Range: 88-92%)
      • Intermediate: 94% (Range: 92-96%)
      • High: 98% (Range: 96-100%)
    • Outcome indicators
      • Primary: Number of days alive and ventilator free by day 28 of hospital admission
      • Secondary: Mortality at 28 days
    • No significant difference was seen for either primary or secondary outcomes between all three groups at 28 days
  • This study shows that the target oxygenation level  is not likely to significantly impact outcomes in mechanically ventilated patients in the ED


Semler MW, Casey JD, Lloyd BD, et al. Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation. N Engl J Med. Nov 10 2022;387(19):1759-1769. doi:10.1056/NEJMoa2208415

Summarized by Mark O’Brien, MS4 | Edited by John Spartz, MD, & Erik Verzemnieks, MD

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