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עברית
Contributor: Aaron Lessen MD
Educational Pearls:
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A recent randomized controlled trial compared ondansetron 8 mg IV with droperidol 2.5 mg IV for the treatment of nausea & vomiting in the emergency department.
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Overall, droperidol and ondansetron had similar primary outcomes in acute nausea control
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Symptom improvement in 93% of patients receiving droperidol vs. 87% receiving ondansetron (P = 0.362)
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Secondary measures were, however, statistically significantly different between groups
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Patients needed fewer rescue/additional antiemetics in the droperidol group (16%) compared with the ondansetron group (37%); p = 0.016
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Similarly, more patients in the droperidol group reported they achieved the desired effect of the medication (85% vs. 63%; p = 0.006)
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Patients receiving droperidol did experience increased drowsiness
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40% in the droperidol group vs. 11% in the ondansetron group
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The trial did not assess the length of stay in the ED after administering medications, which is a potential avenue for future research.
References
1. Philpott L, Clemensen E, Lau GT. Droperidol versus ondansetron for nausea treatment within the emergency department. EMA – Emerg Med Australas. 2023;(December 2022):605-611. doi:10.1111/1742-6723.14174
