Ida Leah Gitajn, MD, MS1; Paul Werth, PhD1; Eseosa Fernandes, MD2; et alSheila Sprague, PhD3; Nathan N. O’Hara, PhD2; Sofia Bzovsky, MSc3; Lucas S. Marchand, MD4; Joseph Thomas Patterson, MD5; Christopher Lee, MD6; Gerard P. Slobogean, MD, MPH2; for the PREP-IT Investigators Author Affiliations Article Information JAMA Netw Open. 2022;5(11):e2244357. doi:10.1001/jamanetworkopen.2022.44357 Key PointsQuestion Are there patient-level or systemic