%PDF-1.7
%
1 0 obj
<<
/PageMode /UseOutlines
/Names 2 0 R
/Outlines 3 0 R
/Metadata 4 0 R
/AcroForm 5 0 R
/Pages 6 0 R
/PageLayout /SinglePage
/OpenAction [7 0 R /FitH 810]
/Threads [8 0 R]
/StructTreeRoot 9 0 R
/Type /Catalog
/Lang (en)
>>
endobj
10 0 obj
<<
/CreationDate (D:20210504134551+05'30')
/Subject (Journal of Allergy and Clinical Immunology, Corrected proof. doi:10.1016/j.jaci.2021.03.042)
/Author (Nandinee Patel MD)
/Creator (Elsevier)
/Producer (Acrobat Distiller 8.1.0 \(Windows\))
/ElsevierWebPDFSpecifications (7.0)
/robots (noindex)
/ModDate (D:20210504135600+05'30')
/doi (10.1016/j.jaci.2021.03.042)
/Title (Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis)
>>
endobj
2 0 obj
<<
/Dests 11 0 R
>>
endobj
3 0 obj
<<
/First 12 0 R
/Count 13
/Last 12 0 R
>>
endobj
4 0 obj
<<
/Length 6525
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
doi:10.1016/j.jaci.2021.03.042
Use of multiple epinephrine doses in anaphylaxis: A systematic review and meta-analysis
Nandinee Patel MD
Kok Wee Chong MD
Alexander Y.G. Yip BSc
Despo Ierodiakonou MD PhD
Joan Bartra MD PhD
Robert J. Boyle MD PhD
Paul J. Turner FRCPCH PhD
Epinephrine
allergic reaction
anaphylaxis
autoinjector device
refractory anaphylaxis
Journal of Allergy and Clinical Immunology, Corrected proof. doi:10.1016/j.jaci.2021.03.042
Elsevier Inc.
journal
Journal of Allergy and Clinical Immunology
© 2021 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.
0091-6749
10.1016/j.jaci.2021.03.042
https://doi.org/10.1016/j.jaci.2021.03.042
P
7.0
10.1016/j.jaci.2021.03.042
noindex
Elsevier
2021-05-04T13:45:51+05:30
2021-05-04T13:56+05:30
2021-05-04T13:56+05:30
True
Acrobat Distiller 8.1.0 (Windows)
uuid:26a99e98-d362-41fc-8187-488b73cdd46f
uuid:9a77dc9d-89d9-4357-97ea-6b0f9ea52375
http://creativecommons.org/licenses/by/4.0/
endstream
endobj
5 0 obj
<<
/Fields []
/DA (/Helv 0 Tf 0 g )
/DR <<
/Font <<
/Helv 13 0 R
/ZaDb 14 0 R
>>
/Encoding <<
/PDFDocEncoding 15 0 R
>>
>>
>>
endobj
6 0 obj
<<
/Count 9
/Type /Pages
/Kids [7 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R]
>>
endobj
7 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R
34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R
44 0 R 45 0 R]
/Parent 6 0 R
/B [46 0 R 47 0 R 48 0 R 49 0 R 50 0 R]
/Contents [51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 60 0 R
/Type /Page
>>
endobj
8 0 obj
<<
/F 46 0 R
/I 61 0 R
>>
endobj
9 0 obj
<<
/K [62 0 R 63 0 R 64 0 R]
/ParentTree 65 0 R
/ParentTreeNextKey 4
/Type /StructTreeRoot
>>
endobj
11 0 obj
<<
/Kids [66 0 R 67 0 R 68 0 R]
>>
endobj
12 0 obj
<<
/First 69 0 R
/Parent 3 0 R
/Dest
/Count 12
/Last 70 0 R
/Title
>>
endobj
13 0 obj
<<
/Subtype /Type1
/Name /Helv
/BaseFont /Helvetica
/Encoding 15 0 R
/Type /Font
>>
endobj
14 0 obj
<<
/Subtype /Type1
/Name /ZaDb
/BaseFont /ZapfDingbats
/Type /Font
>>
endobj
15 0 obj
<<
/Differences [24 /breve /caron /circumflex /dotaccent /hungarumlaut /ogonek /ring /tilde 39
/quotesingle 96 /grave 128 /bullet /dagger /daggerdbl /ellipsis /emdash /endash
/florin /fraction /guilsinglleft /guilsinglright /minus /perthousand /quotedblbase /quotedblleft /quotedblright /quoteleft
/quoteright /quotesinglbase /trademark /fi /fl /Lslash /OE /Scaron /Ydieresis /Zcaron
/dotlessi /lslash /oe /scaron /zcaron 160 /Euro 164 /currency 166
/brokenbar 168 /dieresis /copyright /ordfeminine 172 /logicalnot /.notdef /registered /macron
/degree /plusminus /twosuperior /threesuperior /acute /mu 183 /periodcentered /cedilla /onesuperior
/ordmasculine 188 /onequarter /onehalf /threequarters 192 /Agrave /Aacute /Acircumflex /Atilde
/Adieresis /Aring /AE /Ccedilla /Egrave /Eacute /Ecircumflex /Edieresis /Igrave /Iacute
/Icircumflex /Idieresis /Eth /Ntilde /Ograve /Oacute /Ocircumflex /Otilde /Odieresis /multiply
/Oslash /Ugrave /Uacute /Ucircumflex /Udieresis /Yacute /Thorn /germandbls /agrave /aacute
/acircumflex /atilde /adieresis /aring /ae /ccedilla /egrave /eacute /ecircumflex /edieresis
/igrave /iacute /icircumflex /idieresis /eth /ntilde /ograve /oacute /ocircumflex /otilde
/odieresis /divide /oslash /ugrave /uacute /ucircumflex /udieresis /yacute /thorn /ydieresis]
/Type /Encoding
>>
endobj
16 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R
81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R
91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R 100 0 R
101 0 R 102 0 R 103 0 R 104 0 R 105 0 R]
/Parent 6 0 R
/B [106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R
116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R]
/Contents [122 0 R 123 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 124 0 R
/Type /Page
>>
endobj
17 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [125 0 R 126 0 R]
/Parent 6 0 R
/B [127 0 R]
/StructParents 1
/Contents [128 0 R 129 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 130 0 R
/Type /Page
>>
endobj
18 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Parent 6 0 R
/StructParents 2
/Contents [131 0 R 132 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 133 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R 140 0 R 141 0 R 142 0 R 143 0 R
144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R 151 0 R]
/Parent 6 0 R
/B [152 0 R 153 0 R 154 0 R 155 0 R]
/Contents [156 0 R 157 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 158 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [159 0 R 160 0 R 161 0 R 162 0 R]
/Parent 6 0 R
/B [163 0 R 164 0 R]
/StructParents 3
/Contents [165 0 R 166 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 167 0 R
/Type /Page
>>
endobj
21 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R
178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R
188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R
198 0 R 199 0 R 200 0 R]
/Parent 6 0 R
/B [201 0 R 202 0 R 203 0 R 204 0 R]
/Contents [205 0 R 206 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 207 0 R
/Type /Page
>>
endobj
22 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R
218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R 226 0 R 227 0 R
228 0 R 229 0 R 230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R
238 0 R 239 0 R 240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R
248 0 R 249 0 R 250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R
258 0 R 259 0 R 260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R
268 0 R 269 0 R 270 0 R 271 0 R 272 0 R 273 0 R 274 0 R 275 0 R 276 0 R 277 0 R
278 0 R 279 0 R 280 0 R 281 0 R 282 0 R 283 0 R 284 0 R 285 0 R 286 0 R 287 0 R
288 0 R 289 0 R 290 0 R 291 0 R 292 0 R 293 0 R 294 0 R 295 0 R 296 0 R 297 0 R
298 0 R 299 0 R 300 0 R 301 0 R 302 0 R 303 0 R 304 0 R 305 0 R 306 0 R 307 0 R
308 0 R 309 0 R 310 0 R 311 0 R 312 0 R 313 0 R 314 0 R 315 0 R 316 0 R 317 0 R
318 0 R 319 0 R 320 0 R 321 0 R 322 0 R 323 0 R 324 0 R 325 0 R 326 0 R 327 0 R
328 0 R 329 0 R 330 0 R 331 0 R 332 0 R 333 0 R 334 0 R 335 0 R 336 0 R 337 0 R
338 0 R 339 0 R 340 0 R 341 0 R 342 0 R 343 0 R 344 0 R 345 0 R 346 0 R 347 0 R
348 0 R 349 0 R 350 0 R 351 0 R 352 0 R 353 0 R 354 0 R 355 0 R 356 0 R 357 0 R
358 0 R 359 0 R]
/Parent 6 0 R
/B [360 0 R 361 0 R]
/Contents [362 0 R 363 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 364 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/CropBox [0 0 584.957 782.986]
/Annots [365 0 R 366 0 R 367 0 R 368 0 R 369 0 R 370 0 R 371 0 R 372 0 R 373 0 R 374 0 R
375 0 R 376 0 R 377 0 R 378 0 R 379 0 R 380 0 R 381 0 R 382 0 R 383 0 R 384 0 R
385 0 R 386 0 R 387 0 R 388 0 R 389 0 R 390 0 R 391 0 R 392 0 R 393 0 R 394 0 R
395 0 R 396 0 R 397 0 R 398 0 R 399 0 R 400 0 R 401 0 R 402 0 R 403 0 R 404 0 R
405 0 R 406 0 R 407 0 R 408 0 R 409 0 R 410 0 R 411 0 R 412 0 R 413 0 R 414 0 R
415 0 R 416 0 R 417 0 R 418 0 R 419 0 R 420 0 R 421 0 R 422 0 R 423 0 R 424 0 R
425 0 R 426 0 R 427 0 R 428 0 R 429 0 R 430 0 R 431 0 R 432 0 R 433 0 R 434 0 R
435 0 R 436 0 R 437 0 R 438 0 R 439 0 R 440 0 R 441 0 R 442 0 R 443 0 R 444 0 R
445 0 R 446 0 R 447 0 R 448 0 R 449 0 R 450 0 R 451 0 R 452 0 R 453 0 R 454 0 R
455 0 R 456 0 R 457 0 R 458 0 R 459 0 R 460 0 R 461 0 R 462 0 R 463 0 R 464 0 R
465 0 R 466 0 R 467 0 R 468 0 R 469 0 R 470 0 R 471 0 R 472 0 R 473 0 R 474 0 R
475 0 R 476 0 R 477 0 R 478 0 R 479 0 R 480 0 R 481 0 R 482 0 R 483 0 R 484 0 R
485 0 R 486 0 R 487 0 R 488 0 R 489 0 R 490 0 R 491 0 R 492 0 R 493 0 R 494 0 R
495 0 R 496 0 R 497 0 R 498 0 R 499 0 R]
/Parent 6 0 R
/B [500 0 R 501 0 R]
/Contents [502 0 R 503 0 R]
/Rotate 0
/MediaBox [0 0 584.957 782.986]
/Resources 504 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/Rect [106.809 637.455 106.809 639.269]
/Subtype /Link
/A 505 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
25 0 obj
<<
/Rect [204.605 637.455 204.605 639.269]
/Subtype /Link
/A 506 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
26 0 obj
<<
/Rect [317.424 637.455 317.424 639.269]
/Subtype /Link
/A 507 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
27 0 obj
<<
/Rect [433.644 637.455 433.644 639.269]
/Subtype /Link
/A 508 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
28 0 obj
<<
/Rect [90.822 624.472 90.822 626.286]
/Subtype /Link
/A 509 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
29 0 obj
<<
/Rect [203.981 624.472 203.981 626.286]
/Subtype /Link
/A 510 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
30 0 obj
<<
/Rect [328.989 624.472 328.989 626.286]
/Subtype /Link
/A 511 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
31 0 obj
<<
/Rect [349.568 367.71 353.083 377.178]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
32 0 obj
<<
/Rect [330.52 356.768 334.091 366.236]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
33 0 obj
<<
/Rect [460.063 345.77 463.635 355.238]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
34 0 obj
<<
/Rect [465.392 345.77 468.964 355.238]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
35 0 obj
<<
/Rect [342.142 247.181 345.713 256.649]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
36 0 obj
<<
/Rect [430.639 225.241 440.447 234.709]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
37 0 obj
<<
/Rect [379.162 148.535 382.734 158.003]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
38 0 obj
<<
/Rect [384.491 148.535 388.063 158.003]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
39 0 obj
<<
/Rect [389.82 148.535 406.375 158.003]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
40 0 obj
<<
/Rect [365.839 93.713 372.926 103.181]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
41 0 obj
<<
/Rect [403.937 93.713 407.509 103.181]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
42 0 obj
<<
/Rect [258.52 105.505 286.923 112.479]
/Subtype /Link
/A 512 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
43 0 obj
<<
/Rect [48.813 96.548 88.951 103.521]
/Subtype /Link
/A 513 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
44 0 obj
<<
/Rect [68.598 60.661 191.395 67.635]
/Subtype /Link
/A 514 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
45 0 obj
<<
/Rect [41.839 51.704 158.457 58.677]
/Subtype /Link
/A 515 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
46 0 obj
<<
/N 47 0 R
/P 7 0 R
/R [39 714 290 720]
/T 8 0 R
/V 501 0 R
>>
endobj
47 0 obj
<<
/N 48 0 R
/P 7 0 R
/R [39 658 454 728]
/T 8 0 R
/V 46 0 R
>>
endobj
48 0 obj
<<
/N 49 0 R
/P 7 0 R
/R [39 607 550 654]
/T 8 0 R
/V 47 0 R
>>
endobj
49 0 obj
<<
/N 50 0 R
/P 7 0 R
/R [39 358 290 596]
/T 8 0 R
/V 48 0 R
>>
endobj
50 0 obj
<<
/N 106 0 R
/P 7 0 R
/R [299 54 550 596]
/T 8 0 R
/V 49 0 R
>>
endobj
51 0 obj
<<
/Length 1442
/Filter /FlateDecode
>>
stream
H|Vn8}W*jEڧ&t7ݴAX}%b#.q;CJE 3gg1Yf4 h&ۀm=Ň/4XuD(Oy %